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Concerned About Good Heart Health? You Should Be!
Coronary Heart Disease (CHD) typically begins when,
for one reason or another, the heart is unable to get the proper
supply of blood, oxygen, energy or some combination of the three.
Because the heart is a muscle and muscles need oxygen and energy
in order to repair/rebuild themselves, it is of utmost importance
to make sure your heart is getting the energy it needs.
Whether you suffer from CHD or just want to maintain
good heart health, you should consider supplementing your diet with
Wellness Partners RiboPure Crystals.
Who needs supplemental ribose?
Everyone needs ribose. It is an essential ingredient in stimulating
natural energy production. Research has shown that ribose promotes
cardiovascular health, reduces cardiac stress associated with strenuous
activity and helps athletes reach new heights. Ribose helps hearts
and muscles maximize energy recovery. Whether you are a trained
athlete, a weekend warrior or are concerned about your cardiovascular
health, ribose may help give the energy boost your body needs.
What will ribose do for someone concerned about
cardiovascular health?
Numerous medical studies have shown that energy levels in the heart
can be dramatically lowered by exercise or decreased blood flow
associated with certain cardiac diseases. Depleted cardiac energy
pools may be associated with increased cardiac stress, reduced blood
flow to the periphery of the body, fatigue and decreased exercise
tolerance. Ribose is the key nutrient for quickly restoring cardiac
energy stores.
Recovery For Your Heart
Clinical and laboratory studies on the hearts of both animals and
humans have shown many positive benefits of ribose including ventricular
function (that is -- how well the heart is pumping blood) and enhanced
recovery of energy-carrying nucleotide levels following ischemia
(that is -- a lack of oxygen to tissues), and increased abililty
to tolerate exercise in patients with stable coronary artery disease.
Low Blood Flow
When the flow of blood to the heart is impeded, it results in a
substantial lowering of tissue energy. We know that this is the
case because we see a decrease in the level of ATP (energy) in the
heart tissues. With less energy comes a less efficient heart.2,3
Because this situation can occur in patients experiencing heart
problems as well as those recovering from a surgical procedure where
the blood flow was stopped for an extended period of time, researchers
have been looking for ways to provide energy to the tissues in the
form of a supplement.
In a series of oxygen depletion studies it was found that the process
the body goes through to synthesize energy for the cells was impaired
greatly.12,13,24,25 By providing ribose to
the heart, the process of synthesizing energy is stimulated. The
presence of ribose allows the body to skip several steps in the
synthesizing process, leading to the production of PRPP.
This increase in PRPP levels is noted to be accompanied by accelerated
cardiac adenine nucleotide synthesis and improved global heart function.
Thus, ribose restores cardiac energy reserves and positively affects
myocardial function.
Coronary Heart Disease and Exercise
The effect of orally-administered ribose on exercise tolerance
in stable coronary artery disease patients has also been studied.26
Patients were randomized into two groups. Ten patients received
placebo (glucose) for three days and another 10 patients received
ribose dissolved in water for the same time period. A treadmill
evaluation was performed in all patients after taking the supplement.
In the ribose-treated group, the mean walking time to the exercise
threshold was significantly greater than in the placebo group (p
< 0.002). The time to both the threshold and the onset of moderate
angina was also prolonged significantly in the ribose group compared
to its pre-ribose baseline (p<0.005).
These results show that patients who had been given ribose were
able to exercise longer without chest pain or evidence of ischemia
than patients who did not receive ribose.
Ribose and Cardiomyopathy
Another research study reported that ribose infusion in conjunction
with dobutamine stress echocardiography increases the contractile
response in hibernating regions of the heart.31
In a placebo-controlled double-blind study twenty-five patients
with ischemic cardiomyopathy were infused with either D-ribose or
dextrose placebo for the 4 hours prior to dobutamine stress echocardiography.
On day two the patients were crossed over to the alternate treatment.
During dobutamine stress echocardiography more dysfunctional wall
segments responded with improved wall motion when D-ribose was infused
prior to the procedure as compared to placebo (p = 0.02). In patients
who then underwent coronary artery bypass surgery the predictive
sensitivity for functional recovery of the segments identified during
the D-ribose infusion was greater than those identified during placebo
infusion.
A recent review provides the background and rationale for the use
of ribose in metabolic support of the heart.32
Evidence such as that discussed above is presented in support of
the main hypothesis that ribose is the rate-limiting component (that
is -- one with the ability to bypass several steps in the synthesis
of energy) in the pathways necessary for the heart to restore depleted
adenine nucleotide levels.
References
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