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Wellness Partners d Ribose Ribopure Crystals Provide Maximum Muscle Recovery & Maximum Cardiac Protection!

Ribose and its Effect on Energy Recovery in Heart and Skeletal Muscle

by Terri L. Butler, Ph.D.
Bioenergy, Inc.

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References

1. Benson, E. S., G. T. Evans, and B. E. Hallaway. Myocardial creatine phosphate and nucleotides in anoxic cardiac arrest and recovery. Am. J. Physiol. 201: 687, 1961.

2. Foker, J. E., S. Einzig, and T. Wang. Adenosine metabolism and myocardial preservation. J. Thorac. Cardiovasc. Surg. 80: 506-516, 1980.

3. Pasque, M. K. and A. Wechsler. Metabolic intervention to affect myocardial recovery following ischemia. Annals of Surgery 200: 1-10, 1984.

4. Lee, H. T., R. J. LaFaro, and G. E. Reed. Pretreatment of human myocardium with adenosine during open heart surgery. J Card. Surg. 10: 665-676, 1995.

5. Jennings, R. B. and C. Stanbergen, Jr. Nucleotide metabolism and cellular damage in myocardial ischemia. Annual Rev. Physiol. 47: 727 - 749, 1985.

6. Ward, H. B., J. A. St. Cyr, J. A. Cogordan, D. Alyono, R. W. Bianco, J. M. Kriett, & J. E. Foker. Recovery of adenine nucleotide levels after global myocardial ischemia in dogs, Surgery 96(2): 248-255, 1984.

7. Stathis, C. G., M. A. Febbraio, M. F. Carey, and R. J. Snow. Influence of sprint training on human muscle purine nucleotide metabolism. J. of Appl. Physiol. 76(4): 1802-1809, 1994.

8. Hellsten-Westing, Y., P. D. Balsom, B. Norman, and B. Sjodin. The effect of high-intensity training on purine metabolism in man. Acta Physiol. Scand. 149: 405-412, 1993.

9. Hellsten-Westing, Y., B. Norman, P. D. Balsom, and B. Sjodin. Decreased resting levels of adenine nucleotides in human skeletal muscle after high-intensity training. J. Appl. Physiol. 74(5): 2523-2528, 1993.

10. Tullson, P. C. and R. L. Terjung. Adenine nucleotide synthesis in exercising and endurance-trained skeletal muscle. Am. J. Physiol. 261: C342-C347, 1991.

11. Tullson, P. C., J. Bangsbo, Y. Hellsten, and E. A. Richter. IMP metabolism in human skeletal muscle after exhaustive exercise. J. Appl. Physiol. 78: 146-152, 1995.

12. Zimmer, H.-G. and E. Gerlach. Stimulation of myocardial adenine nucleotide biosynthesis by pentoses and pentitols. Pflugers Arch. 376: 223 - 227, 1978.

13. Zimmer, H.-G. Restitution of myocardial adenine nucleotides: acceleration be administration of ribose. J. Physiol., Paris 76(7): 769 - 775, 1980.

14. Zimmer, H.-G. and J. Schad. Ribose intervention in the cardiac pentose phosphate pathway is not species-specific. Science 223: 712 - 713, 1984.

15. Zimmer, H.-G. Regulation of and intervention into the oxidative pentose phosphate pathway and adenine nucleotide metabolism in the heart. Molec. Cell. Biochem. 160/161: 101 - 109, 1996.

16. Pasque, M. K., T. L. Spray, G. L. Pellom, P. Van Trigt, R. B. Peyton, W. D. Currie, and A. S. Wechsler. Ribose-enhanced myocardial recovery following ischemia in the isolated working rat heart, J. Thorac. Cardiovasc. Surg. 83(3): 390-398, 1982.

17. St. Cyr, J. A., H. Ward, J. Kriett, D. Alyono, S. Einzig, R. Bianco, R. Andersoon, and J. Foker. Long term model for evaluation of myocardial metabolic recovery following global ischemia. In: N. Bratbar (ed.) Myocardial and Skeletal Muscle Bioenergetics pp. 401 -414, Plenum, New York, 1986.

18. St. Cyr, J. A., R. W. Bianco, J. R. Schneider, J. R. Mahoney, K. Tveter, S. Einzig, and J. E. Foker. Enhanced high energy phosphate recovery with ribose infusion after global myocardial ischemia in a canine model. J. Surg. Res. 46, 157 - 162, 1989.

19. Chatham, J. C., R. A. J. Challiss, G. K. Radda, and A-M. L. Seymour. Studies of the protective effect of ribose in myocardial ischaemia by using 31P-nuclear-magnetic-resonance spectroscopy. Biochem. Soc. Trans. 13: 885 - 886, 1985.

20. Hiatt, H. H. Glycogen formation via the pentose phosphate pathway in mice in vivo. J. Biol. Chem. 224: 851 - 859, 1957.

21. Segal, S. and J. Foley. The metabolism of D-ribose in man. J. Clinical Invest. 37: 719 - 735, 1958.

22. Bloom, B., F. J. Eisenberg, and D. J. Stetten. Glucose catabolism in liver slices via the phospho-gluconate oxidation pathway, J. Biol., Chem. 215: 461 - 466, 1954.

23. Coffey, R.G., Morse H., and Newburgh R.W. The synthesis of nucleic acid constituents in the early chick embryo, Biochim. Biophys. Acta 114: 547-558, 1965.

24. Zimmer, H.-G., H. Ibel, and G. Steinkopff. Studies on the hexose monophosphate shunt in the myocardium during development of hypertrophy. In: Advances in Myocardiology Volume 1 (eds. M Tajuddin, P. K. Das, M. Tariq, and N. S. Dhalla) pp. 487 - 492, University Park Press, Baltimore, 1980.

25. Zimmer, H.-G. and H. Ibel. Effects of ribose on cardiac metabolism and function in isoproterenol-treated rats. Am. J. Physiol. 245: H880 - H886, 1983.

26. Pliml, W, T. von Arnim, A. Stablein, H. Hofmann, H.-G. Zimmer, and E. Erdmann. Effects of ribose on exercise-induced ischaemia in stable coronary artery disease. Lancet 340: 507 - 510, 1992.

27. Angello, D. A., R. A. Wilson, D. Gee, and N. Perlmutter. Recovery of myocardial function and thallium-201 redistribution using ribose. Am. J. Card. Imaging 3(4): 256 - 265, 1989.

28. Angello, D. A., R. A. Wilson, and D. Gee. Effect of ribose on thallium-201 myocardial redistribution. J. Nucl. Med 29: 1943 - 1950, 1988.

29. Perlmutter, N. S., R. A. Wilson, D. A. Angello, R. T. Palac, J. Lin, and B. G. Brown. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J. Nucl. Med. 32: 193- 200, 1991.

30. Hegewald, M. G., R. T. Palac, D. A. Angello, N. S. Perlmutter, and R. A. Wilson. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J. Am. Coll. Cardiol. 18: 1671 - 1681, 1991.

31. Gradus-Pizlo, I., S. Sawada, S. Lewis, S. Khouri, D. Segar, R. Kovacs, and H. Feigenbaum. Effect of D-ribose on the detection of the hibernating myocardium during the low dose dobutamine stress echocardiography. Circulation Suppl. 100(18):3394, 1999.

32. Pauli, D.F. and C.J. Pepine. D-ribose as a supplement for cardiac energy metabolism. J. Cardiovasc. Pharmacol. Therapeut. 5:249-258, 2000.

33. Brault, J.J. and R.L. Terjung. Purine salvage rates differ among skeletal muscle fiber types and are limited by ribose supply. Med. Sci. Sports Exer. Suppl. 31(5): 1365, 1999.

34. Zarzeczny, R., J. Brault, K. Abraham, C. Hancock, and R.L. Terjung. Purine salvage is not reduced during recovery following intense contractions. Med. Sci. Sports Exer. Suppl. 32(5): 214, 2000.

35. Brault, J.J., R.L. Terjung. Attempted expansion of resting muscle ATP content by a prolonged period of adenine salvage Med. Sci. Sports Exer. Suppl. 32(5): 213, 2000.

36. Witter, J., P. Gallagher, D. Williamson, M. Godard, and S. Trappe. Effects of ribose supplementation on performance during repeated high-intensity cycle sprints. Midwest Regional Chapter of the ACSM, October 2000.

37. Gallagher, P.M., D.L. Williamson, M.P. Godard, J. Witter, S.W. Trappe. Effects of ribose supplementation on adenine nucleotide concentration in skeletal muscle following high-intensity exercise. Midwest Regional Chapter of the ACSM, October 2000.

38. Antonio, J. D. Van Gammeren, and D. Falk. The effects of ribose supplementation of exercise performance in recreational male bodybuilders. Data on file at Bioenergy, Inc., 13840 Johnson Street N.E., Ham Lake, Minnesota 55304 USA.

Use of ribose is authorized by Bioenergy, Inc. under U.S. patents 4,605,644; 4,719,201; 6,159,942; 6,159,943 and others pending.

Bioenergy, Inc., December 2000.

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