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Ribose and its Effect on Energy Recovery in Heart and Skeletal Muscle by Terri L. Butler, Ph.D. Back to About Ribose Ribose is a naturally occurring pentose monosaccharide. It is used by the body to synthesize nucleotides, nucleic acids, glycogen, and other important metabolic products. Ribose is formed in the body from conversion of glucose via the pentose phosphate pathway (PPP, also known as the hexosemonophosphate shunt or the phosphogluconate pathway, Figure 1).
Figure 1. The pentose phosphate pathway (PPP) and the point of entry for ribose into the pathway. 5-phosphoribosyl-1-pyrophosphate is represented as PRPP. Supplemental ribose enters the PPP by being phosphorylated to R-5-P by ribokinase. The R-5-P thus formed can be utilized to a) generate glucose by reverse flux up the PPP 20, 21; b) form pyruvate through glycolysis 21, 22; or c) synthesize nucleotides 23 which are needed for ATP production. In this way ribose is utilized in animals and man in many different tissues, including the heart and skeletal muscle. Next Section: Ribose Metabolism Click here to order Wellness Partners RiboPure Crystals!
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