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About Wellness Partners RiboPure Crystals!
What is ribose? D-Ribose is a simple, 5-carbon
monosaccharide, or pentose sugar. It is used by all the cells of
the body and is an essential compound in energy metabolism. Ribose
is also the carbohydrate backbone of genetic material, DNA and RNA,
certain vitamins and other important cellular compounds.
Who needs supplemental ribose? Everyone needs
ribose. It is an essential ingredient in stimulating natural energy
production. Research has shown that ribose promotes cardiovascular
health, reduces cardiac stress associated with strenuous activity
and helps athletes reach new heights. Ribose helps hearts and muscles
maximize energy recovery. Whether you are a trained athlete, a weekend
warrior or are concerned about your cardiovascular health, ribose
may help give the energy boost your body needs.
What is the recommended daily dosage of ribose?
For energy enhancement, ½ to 1 teaspoon (about 2 - 5
grams) is generally adequate. Bioenergy RIBOSE is mildly sweet and
completely soluble. It mixes easily with your favorite juice, milk
or other cold foods.
To maximize athletic performance, or to keep energy pools high
during strenuous activity, slightly larger doses may be required.
Bioenergy RIBOSE should be taken just before and just after exercise
or activity. For extended exercise, an additional 1 - 2 grams per
hour of exercise or activity may be helpful.
Are there any side effects associated with taking ribose? Ribose
should be taken in doses up to 5 grams (approximately 1 rounded
teaspoon) at a time. Multiple 5-gram doses separated by 30 - 45
minutes can be taken without side effects. There are two known side
effects of taking ribose in doses of 10 grams or more on an empty
stomach. The first is a transient hypoglycemia (low blood sugar)
that can be eliminated by taking larger doses of ribose with other
carbohydrates (such as in juice). The second side effect that may
occur in some individuals is loose stools. Again, this side effect
has only been reported in very large doses, greater than 10 grams.
Total daily intake of ribose should be limited to 20 grams, or approximately
4 rounded teaspoonfuls.
The following article was written by Dr. Terri L. Butler of Bioenergy,
Inc., and gives a very good -- albeit in depth and complex -- explanation
of how ribose is synthesized into ATP and why that is important
for your body. Bioenergy, Inc., is the manufacturer of our Wellness
Partners RiboPure Crystals.
Ribose and its Effect on Energy Recovery in Heart
and Skeletal Muscle
by Terri L. Butler, Ph.D.
Bioenergy, Inc.
Introduction
Ribose and its Role in the Pentose Phosphate
Pathway
Ribose Metabolism
Ribose Effects in the Heart
Ribose Effects on Skeletal Muscle
Conclusion
References
Introduction
Under conditions of physical duress the body's energy resources
become depleted. In particular, intracellular levels of the body's
primary energy carrying molecule, adenosine triphosphate (ATP),
are lowered significantly. Since cells and organs need adequate
energy in order to maintain integrity and function, it is essential
that the supply of ATP be replenished soon after it is consumed.
This is possible over the short term in the presence of oxygen
via the respiratory metabolic pathways. However, when the oxygen
supply is inadequate, even temporarily, energy metabolism is impaired
and ATP molecules are not regenerated quickly enough to meet the
body's energy demands.
For example, when the myocardium becomes oxygen depleted due to
ischemia (restricted blood flow to the heart) resulting from occluded
arteries, heart attack, heart surgery, organ transplantation or
other surgery, myocardial levels of ATP will fall dramatically and
can take up to 10 days to recover.1,2,3,4,5,6
Under conditions of such energetic depletion myocardial function
is compromised and there is an increased risk of permanent loss
of myocardial tissue.
Even in lower risk situations, such as healthy individuals who
are pushing their physical limits by intense exercise, ATP reserves
can become depleted and take several days to recover.7,
8, 9, 10, 11
Slow replenishment of ATP in both myocardial and skeletal muscle
tissues has been attributed to the low rate of de novo synthesis
and slow recovery of ATP and its precursors via the salvage pathways.2,
3, 10, 12 Since replenishment of ATP is likely to enhance
the functional recovery of these tissues investigators have sought
methods of improving the salvage rates and increasing de novo synthesis.
Interestingly, in a wide range of studies several investigators
have found that ATP recovery can be stimulated in both myocardial
and skeletal muscle tissues by administering a simple sugar called
ribose. 3, 6, 10, 12, 13, 14, 15, 16, 17, 18, 19
Next Section: Ribose and its Role in the
Pentose Phosphate Pathway
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